Monocyte chemoattractant protein-1: does it play a role in diabetic nephropathy?

Monocyte chemoattractant protein-1: does it play a role in diabetic nephropathy?

Both metabolic and haemodynamic pathways impact on the progressionof diabetic nephropathy [1,2]. Chronic hyperglycaemia, advanced glycation end (AGE) products, increase of sorbitol, activation of protein kinase C (PKC), glomerular hypertension and genetic susceptibility have been identified as risk factors in the progression of diabetic nephropathy [2]. Moreover, infiltration of the diseased ki...

Urine Monocyte Chemoattractant Protein-1(UMCP-1) as a Biomarker of Renal Involvement in Systemic Lupus Erythematosus

Objective(s)Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study,s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UMCP-1) as a biomarker of renal involvement in systemic lupus erythematosus.Mate...

Monocyte Chemoattractant Protein-1 Synthesis

Role of Monocyte Chemoattractant Protein-1 in Myocardial Infarction

Myocardial infarction (MI) is accompanied by inflammatory responses that lead to the recruitment of leukocytes and subsequent myocardial damage, healing, and scar formation. Chemokines are a family of potent chemoattractant cytokines that regulate the leukocyte trafficking in basal levels and inflammatory processes; however, it has been recently recognized that chemokines are expressed by non-h...

Serum Levels of Monocyte Chemoattractant Protein-1 Correlate with Poor Clinical Grades in Cerebral Aneurysms

Background : Ruptured cerebral aneurysms (ICAs) are the most common non-traumatic cause of subarachnoid hemorrhage (SAH) that is associated with life threatening complications such as Vasospasm, Infarction, and Hydrocephalus (HCP). The active participation of macrophage/monocyte-mediated inflammatory response in the pathogenesis of cerebral aneurysm as labeled with Monocyte ChemoattractantProte...